Evaluation of Rifamycin SV and Rifampin Kinetics in Lactating Ewes

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Evaluation of rifamycin SV and rifampin kinetics in lactating ewes.

Serum and milk concentrations of rifamycin SV and rifampin were determined in lactating ewes after a single intravenous injection, and pharmacokinetic parameters were evaluated by the two-compartment open-system model. Rifampin was distributed throughout a greater volume than rifamycin SV and was eliminated more slowly from the body. The concentrations of the two drugs, both lipophilic weak aci...

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A patient developed severe anaphylaxis during irrigation of a wound with rifamycin SV. The temporal relationship between application of rifamycin SV, the positive skin test and basophil activation test for rifamycin SV strongly supported diagnosis of anaphylaxis from the locally applied antibiotic. However, after operation the patient had two anaphylactic reactions with pruritus, urticaria and ...

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The antimycobacterial activities of a new rifampin (RIF) derivative, 3-(4-cinnamylpiperazinyl iminomethyl) rifamycin SV (To), against 20 susceptible and multidrug-resistant strains of Mycobacterium tuberculosis and 20 Mycobacterium avium complex (MAC) strains were investigated. The radiometric MICs of T9 for M. tuberculosis were significantly lower than those of RIF. The MICs of T9 and RIF at w...

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An Australian isolate of Nocardia mediterranea producing rifamycin SV.

Since its first announcement by P. Sensi et at. in 19591}, the rifamycin complex has been extensively studied by a number of workers2). The type culture Nocardia mediterranea (Margalith et Beretta) Thiemann et at. 1969*, then known as Streptomyces mediterranei^ was isolated from a soil sample collected in France. Sugawara et al.l) culturing an isolate (4107 A2) from a Japanese soil sample, repo...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1974

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.5.2.139